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Department of Chemistry Organic Chemistry & The Chemistry of Biological Systems

Chemistry of Biological Systems News

 

  • The 2018 Matteson Symposium will be held September 22nd 2018 and will focus on drug discovery.  Please follow the menu on the left for more information.

  • Troy Hall Remodel Complete!  Rock Mancini and Ming Xian have moved to this state-of-the-art research space.

 

Group News

News from the Mancini Lab

  • The Mancini Group recently converted their Bystander-Assisted Immunotherapy patent and established the field of enzyme-directed immunostimulants. Mancini, RJ et al., United States Patent, 15/722,018, October 2, 2017
  • New publications include:
    • Mancini, RJ et al., Langmuir, 2016, 32(16), 4043
    • Hantho, JD et al., ChemMedChem, 2016, 11(22), 2496
    • Ryu, KA et al., Nature Scientific Reports, 2017, 7, 8074
    • Nielsen AE et al., Future Medicinal Chemistry, 2017, 9(12), 1345
    • Burt, AJ et al., Biochemistry, 2018, ASAP (https://pubs.acs.org/doi/abs/10.1021/acs.biochem.8b00095)

News from the Xian Lab

  • The Xian lab developed new near-infrared fluorescent dyes named Washington Red, offering remarkable potential for bioimaging advancement. See WSU News  https://news.wsu.edu/2017/12/11/bioimaging-dye-breakthrough/
  • Graduate student Jacob Day receives a prestigious NIH pre-doctoral fellowship (aka the Ruth L. Kirschstein National Research Service Award). See WSU News: https://news.wsu.edu/2017/05/09/chemistry-student-mistake-becomes-fellowship/
  • The Xian lab received a NIH R01 grant to support their research on reactive sulfur species. They also received a NSF grant to support their data-driven optimization of fluorescent sensors based on advanced machine learning and data mining techniques.

News from the Garner Lab

  • Teaming up with collaborators from Scripps, Prof. Garner and graduate student Dan Collins gave the thioester its debut as an amino acid side chain via site-specific incorporation of a non-natural amino acid into proteins (https://pubs.acs.org/doi/abs/10.1021/acschembio.7b00998). This work sets the stage for the controlled chemical introduction of a variety of protein modifications, including glycosylation, which is an ongoing project in the Garner group.